ACY1 Antibody

Aminoacylase-1 (ACY1) is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of N-acetylated amino acids to free amino acids and acyl groups . This enzyme plays a crucial role in the catabolism and salvage of acylated amino acids. The gene encoding ACY1 is located on chromosome 3p21.1 in humans .

ACY1 is involved in various biological processes, including the detoxification of aflatoxins and glycosylation disorders . It has been postulated to function in the catabolism and salvage of acylated amino acids, which are essential for maintaining cellular homeostasis .

Mutations in the ACY1 gene can lead to aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids . This deficiency can result in neurological conditions and other metabolic complications .

Recent studies have highlighted the role of ACY1 in myocardial fibrosis and heart failure. For instance, research has shown that the levels of the metabolite N-acetylglutamine are significantly increased in patients with heart failure, while the expression of ACY1 is markedly decreased . This suggests that ACY1 could be a potential therapeutic target for the prevention and treatment of myocardial fibrosis during the development of heart failure .

Mouse anti-human ACY1 antibodies are used in various research applications to study the expression and function of ACY1 in different biological contexts. These antibodies can help in understanding the role of ACY1 in various diseases and in developing potential therapeutic strategies.