ACAA1 Antibody
Description
Product Specs
Product Science Overview
The ACAA2 gene encodes a protein that is approximately 41.9 kDa in size and consists of 397 amino acids . This enzyme catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms . Additionally, it catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA, which is involved in the production of ketone bodies . The enzyme also displays hydrolase activity on various fatty acyl-CoAs, contributing to the production of acetate as a side reaction to beta-oxidation .
Acetyl-CoA Acyltransferase is essential for the metabolism of fatty acids and energy production in cells. It is involved in several biological processes, including the regulation of mitochondrial membrane permeability, cholesterol biosynthesis, and cellular response to hypoxia . The enzyme’s activity is crucial for maintaining normal lipid metabolism and energy homeostasis in the body .
Mutations or variants in the ACAA2 gene have not been directly linked to any clinical diseases. However, the ACAA2 locus has been associated with abnormal blood lipid levels, particularly HDL and LDL cholesterol levels . This association suggests a potential link between ACAA2 and an individual’s risk for coronary artery disease .
The Mouse Anti Human Acetyl-CoA Acyltransferase antibody is used in research to study the expression and function of this enzyme in human tissues. This antibody is typically produced by immunizing mice with human Acetyl-CoA Acyltransferase protein, leading to the generation of specific antibodies that can bind to the human enzyme. These antibodies are valuable tools for investigating the role of Acetyl-CoA Acyltransferase in various biological processes and diseases.
